Protein Complexes Are under Evolutionary Selection to Assemble via Ordered Pathways
نویسندگان
چکیده
منابع مشابه
Protein Complexes Are under Evolutionary Selection to Assemble via Ordered Pathways
Is the order in which proteins assemble into complexes important for biological function? Here, we seek to address this by searching for evidence of evolutionary selection for ordered protein complex assembly. First, we experimentally characterize the assembly pathways of several heteromeric complexes and show that they can be simply predicted from their three-dimensional structures. Then, by m...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.02.044